| Title |
Impact of antibiotics for children presenting to general practice with cough on adverse outcomes: secondary analysis from a multicentre prospective cohort study
|
|---|---|
| Published in |
British Journal of General Practice, September 2018
|
| DOI | 10.3399/bjgp18x698873 |
| Pubmed ID | |
| Authors |
Niamh M Redmond, Sophie Turnbull, Beth Stuart, Hannah V Thornton, Hannah Christensen, Peter S Blair, Brendan C Delaney, Matthew Thompson, Tim J Peters, Alastair D Hay, Paul Little |
| Abstract |
Clinicians commonly prescribe antibiotics to prevent major adverse outcomes in children presenting in primary care with cough and respiratory symptoms, despite limited meaningful evidence of impact on these outcomes. To estimate the effect of children's antibiotic prescribing on adverse outcomes within 30 days of initial consultation. Secondary analysis of 8320 children in a multicentre prospective cohort study, aged 3 months to <16 years, presenting in primary care across England with acute cough and other respiratory symptoms. Baseline clinical characteristics and antibiotic prescribing data were collected, and generalised linear models were used to estimate the effect of antibiotic prescribing on adverse outcomes within 30 days (subsequent hospitalisations and reconsultation for deterioration), controlling for clustering and clinicians' propensity to prescribe antibiotics. Sixty-five (0.8%) children were hospitalised and 350 (4%) reconsulted for deterioration. Clinicians prescribed immediate and delayed antibiotics to 2313 (28%) and 771 (9%), respectively. Compared with no antibiotics, there was no clear evidence that antibiotics reduced hospitalisations (immediate antibiotic risk ratio [RR] 0.83, 95% confidence interval [CI] = 0.47 to 1.45; delayed RR 0.70, 95% CI = 0.26 to 1.90, overall P = 0.44). There was evidence that delayed (rather than immediate) antibiotics reduced reconsultations for deterioration (immediate RR 0.82, 95% CI = 0.65 to 1.07; delayed RR 0.55, 95% CI = 0.34 to 0.88, overall P = 0.024). Most children presenting with acute cough and respiratory symptoms in primary care are not at risk of hospitalisation, and antibiotics may not reduce the risk. If an antibiotic is considered, a delayed antibiotic prescription may be preferable as it is likely to reduce reconsultation for deterioration. |
X Demographics
The data shown below were collected from the profiles of 44 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 17 | 39% |
| Canada | 4 | 9% |
| Spain | 3 | 7% |
| Italy | 2 | 5% |
| United States | 1 | 2% |
| Argentina | 1 | 2% |
| Venezuela, Bolivarian Republic of | 1 | 2% |
| Unknown | 15 | 34% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 28 | 64% |
| Practitioners (doctors, other healthcare professionals) | 8 | 18% |
| Scientists | 4 | 9% |
| Science communicators (journalists, bloggers, editors) | 4 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 48 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 11 | 23% |
| Researcher | 6 | 13% |
| Student > Bachelor | 3 | 6% |
| Student > Doctoral Student | 3 | 6% |
| Other | 3 | 6% |
| Other | 8 | 17% |
| Unknown | 14 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 16 | 33% |
| Nursing and Health Professions | 3 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
| Business, Management and Accounting | 2 | 4% |
| Psychology | 2 | 4% |
| Other | 6 | 13% |
| Unknown | 17 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 87. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 November 2023.
All research outputs
#479,509
of 25,067,172 outputs
Outputs from British Journal of General Practice
#192
of 4,645 outputs
Outputs of similar age
#10,429
of 343,020 outputs
Outputs of similar age from British Journal of General Practice
#7
of 99 outputs
Altmetric has tracked 25,067,172 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,645 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.0. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 343,020 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 99 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.